Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/32990
Título: | A post-mortem study of the anatomical region differences and age-related changes on Ca and Mg levels in the human brain |
Autor(es): | Correia, Hélder Ramos, Patrícia Santos, Agostinho Pinto, Nair Rosas Mendes, Ricardo Magalhães, Teresa Almeida, Agostinho |
Palavras-chave: | Human brain Calcium Magnesium Aging Post-mortem analysis |
Data: | Mar-2014 |
Editora: | Elsevier 1 |
Revista: | Microchemical Journal |
Resumo(s): | Calcium and magnesium levels in 14 different areas of the human brain [frontal cortex, superior and middle temporal gyri, caudate nucleus, putamen, globus pallidus, cingulated gyrus, hippocampus, inferior parietal lobule, visual cortex of the occipital lobe, midbrain, pons-locus coeruleus, medulla and cerebellum-dentate nucleus] of adult individuals (n = 42; 71 +/- 12, range: 50-103 years old) without a known history of neurodegenerative, neurological or psychiatric disorder were studied. Considering the mean values for the 14 regions, Mg was present at ca. 2.3-fold higher levels than Ca (mean +/-: 527 +/- 34 mu g/g versus 226 +/- 53 mu g/g). Calcium distribution within the brain showed to be quite heterogeneous: highest levels were found in the occipital (306 +/- 156 mu g/g) and frontal cortex (287 +/- 78 ug/g), while lowest levels were found in the medulla (186 +/- 70 mu g/g) and cerebellum (145 +/- 42 mu g/g). Higher Ca levels were found in women than in men (248 +/- 59 mu g/g versus 213 +/- 46 mu g/g; p < 0.05). A tendency for Ca levels to increase with age in all studied brain regions and in both genders was also observed. On the contrary, Mg presented a highly homogeneous distribution and seems to remain quite unchanged irrespective of aging. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/32990 |
DOI: | 10.1016/j.microc.2013.11.012 |
ISSN: | 0026-265X |
Versão da editora: | http://www.elsevier.com |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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correia h_microchem j 2014 prep.pdf | 685,83 kB | Adobe PDF | Ver/Abrir |