Proof of concept of the electrochemical sensing of 3-iodothyronamine (T1AM) and Thyronamine (T0AM)

Abstract

Recent studies have shown that, besides the well-recognized T-3 and T-4 hormones, there are other relevant thyroid hormones circulating in the human body. In particular, this is the case for 3-iodothyronamine (T(1)AM) and thyronamine (T(0)AM). One of the reasons for the lack of studies showing their precise importance is the absence of analytical methodologies available. Herein, for the first time, T(1)AM and T(0)AM are electrochemically characterized. T(0)AM was sensed by means of a glassy carbon electrode; furthermore, T(1)AM was sensed both with a graphitic surface (oxidatively) as well as with mercury (reductively). For both compounds, after oxidation, it was possible to observe the reversible redox reaction concerning the benzoquinone/hydroquinone couple, thus increasing the specificity of the electroanalysis. Therefore, this work provides the basis for an at-point-of-use' electrochemical strip test for T(1)AM and T(0)AM.