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https://hdl.handle.net/1822/41573
Título: | Vascular disease modeling using induced pluripotent stem cells: Focus in Hutchinson-Gilford Progeria Syndrome |
Autor(es): | Pereira, P. Rosa, S. C. Praça, C. Ferreira, L. |
Palavras-chave: | Vascular cells Induced pluripotent stem cells Progeria disease Drug modeling Drug screening |
Data: | 6-Mai-2016 |
Editora: | Elsevier 1 |
Revista: | Biochemical and Biophysical Research Communications |
Citação: | Pereira, P.; Rosa, S. C.; Praça, C.; Ferreira, L., Vascular disease modeling using induced pluripotent stem cells: Focus in Hutchinson-Gilford Progeria Syndrome. Biochemical and Biophysical Research Communications, 473(3), 710-718, 2016 |
Resumo(s): | Induced pluripotent stem cells (iPSCs) represent today an invaluable tool to create disease cell models for modeling and drug screening. Several lines of iPSCs have been generated in the last 7 years that changed the paradigm for studying diseases and the discovery of new drugs to treat them. In this article we focus our attention to vascular diseases in particular Hutchinson-Gilford Progeria Syndrome (HGPS), a devastating premature aging disease caused by a mutation in the lamin A gene. In general, patients die because of myocardial infarction or stroke. Because the patients are fragile the isolation of a particular type of cells is very difficult. Therefore in the last 5 years, researchers have used cells derived from iPSCs to model aspects of the HGPS and to screen libraries of chemicals to retard or treat the disease. |
Tipo: | Artigo |
Descrição: | Transparency document related to this article can be found online at http://dx.doi.org/10.1016/j.bbrc.2015.10.014 |
URI: | https://hdl.handle.net/1822/41573 |
DOI: | 10.1016/j.bbrc.2015.10.014 |
ISSN: | 0006-291X |
e-ISSN: | 1090-2104 |
Versão da editora: | http://www.elsevier.com/locate/issn/0006291X |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_23439_1.pdf | 1,03 MB | Adobe PDF | Ver/Abrir |