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https://hdl.handle.net/1822/47100
Título: | Putative biomarkers for cervical cancer: SNVs, methylation and expression profiles |
Autor(es): | Cardoso, Maria de Fátima Senra Castelletti, Carlos Henrique Madeiros Lima-Filho, José Luiz de Martins, Danyelly Bruneska Gondim Teixeira, J. A. |
Palavras-chave: | clinical markers genetic panel prognostic factors therapeutics |
Data: | Jul-2017 |
Editora: | Elsevier 1 |
Revista: | Mutation Research - Reviews in Mutation Research |
Citação: | Cardoso, Maria de Fátima Senra; Castelletti, Carlos Henrique Madeiros; Lima-Filho, José Luiz de; Martins, Danyelly Bruneska Gondim; Teixeira, José A., Putative biomarkers for cervical cancer: SNVs, methylation and expression profiles. Mutation Research - Reviews in Mutation Research, 773, 161-173, 2017 |
Resumo(s): | Cervical cancer is primarily caused by Human papillomavirus (HPV) infection, but other factors such as smoking habits, co-infections and genetic background, can also contribute to its development. Although this cancer is avoidable, it is the fourth most frequent type of cancer in females worldwide and can only be treated with chemotherapy and radical surgery. There is a need for biomarkers that will enable early diagnosis and targeted therapy for this type of cancer. Therefore, a systems biology pipeline was applied in order to identify potential biomarkers for cervical cancer, which show significant reports in three molecular aspects: DNA sequence variants, DNA methylation pattern and alterations in mRNA/protein expression levels. CDH1, CDKN2A, RB1 and TP53 genes were selected as putative biomarkers, being involved in metastasis, cell cycle regulation and tumour suppression. The other ten genes (CDH13, FHIT, PTEN, MLH1, TP73, CDKN1A, CACNA2D2, TERT, WIF1, APC) seemed to play a role in cervical cancer, but the lack of studies prevented their inclusion as possible biomarkers. Our results highlight the importance of these genes. However, further studies should be performed to elucidate the impact of DNA sequence variants and/or epigenetic deregulation and altered expression of these genes in cervical carcinogenesis and their potential as biomarkers for cervical cancer diagnosis and prognosis. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/47100 |
DOI: | 10.1016/j.mrrev.2017.06.002 |
ISSN: | 13835742 |
Versão da editora: | https://www.journals.elsevier.com/mutation-research-reviews |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_46841_1.pdf | 4,18 MB | Adobe PDF | Ver/Abrir |