Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/50504
Título: | Synthesis and biological activity against Mycobacterium tuberculosis of 2,3-dihydroadenine derivatives |
Autor(es): | Correia, Carla Proença, M. Fernanda R. P. Carvalho, M. Alice |
Data: | 2017 |
Editora: | Universidade do Minho. Escola de Ciências (EC) |
Resumo(s): | Purines have attracted attention of the scientific community mainly due to their biological activity [1]. During the last decade, purine derivatives were identified as a promising new class of antitubercular agents. The research was focused on the synthesis of nucleoside analogues as siderophore biosynthesis inhibitors [2], and on non-nucleosides [3]. In the non-nucleoside series, purines having an aryl, a small alkyl or a proton as the 9-N substituent were essentially inactive, whereas 9-benzyl-6-(2-furyl)purines [3a,c,d], 9-sulfonyl-6-mercaptopurines or 6-alkylthiopurines [3b,e] were highly potent. In addition, we recently described the first example of 2,9-diarylpurines active against Mycobacterium tuberculosis (Mtb) [4]. In order to perform SAR studies in the new scaffold, we synthesized novel 2,3-dihydroadenine derivatives. These new molecules represent valuable targets as they possess all the sub units present in the 2-phenolic adenine derivatives that showed activity against Mtb however they allow new conformations. The synthesis of the new derivatives and the biological results obtained against Mtb will be presented. |
Tipo: | Poster em conferência |
URI: | https://hdl.handle.net/1822/50504 |
Arbitragem científica: | no |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CDQuim - Comunicações e Proceedings |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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2017_MAC_3_SympMedChem.pdf Acesso restrito! | 33,14 kB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons