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https://hdl.handle.net/1822/62068
Título: | AMP-activated Protein Kinase As a Target For Pathogens: Friends Or Foes? |
Autor(es): | Moreira, Diana Raquel Bento Silvestre, Ricardo Jorge Leal Cordeiro-da-Silva, Anabela Estaquier, Jérôme Foretz, Marc Viollet, Benoit |
Palavras-chave: | AMP-Activated Protein Kinases Animals Anti-Infective Agents Communicable Diseases Energy Metabolism Enzyme Activation Homeostasis Host-Pathogen Interactions Humans Immunity, Innate Parasites Phosphorylation Protein Interaction Maps Signal Transduction Bacterial Physiological Phenomena Virus Physiological Phenomena Bacteria Infectious diseases Pathogens Pharmacological drugs Therapeutics Virus AMPK-activated protein kinase |
Data: | 2016 |
Editora: | Bentham Science Publishers |
Revista: | Current Drug Targets |
Citação: | Moreira, D., Silvestre, R., Cordeiro-Da-Silva, A., Estaquier, J., Foretz, M., & Viollet, B. (2016). AMP-activated protein kinase as a target for pathogens: friends or foes?. Current drug targets, 17(8), 942-953 |
Resumo(s): | Intracellular pathogens are known to manipulate host cell regulatory pathways to establish an optimal environment for their growth and survival. Pathogens employ active mechanisms to hijack host cell metabolism and acquire existing nutrient and energy store. The role of the cellular energy sensor AMP-activated protein kinase (AMPK) in the regulation of cellular energy homeostasis is well documented. Here, we highlight recent advances showing the importance of AMPK signaling in pathogen-host interactions. Pathogens interact with AMPK by a variety of mechanisms aimed at reprogramming host cell metabolism to their own benefit. Stimulation of AMPK activity provides an efficient process to rapidly adapt pathogen metabolism to the major nutritional changes often encountered during the different phases of infection. However, inhibition of AMPK is also used by pathogens to manipulate innate host response, indicating that AMPK appears relevant to restriction of pathogen infection. We also document the effects of pharmacological AMPK modulators on pathogen proliferation and survival. This review illustrates intricate pathogen-AMPK interactions that may be exploited to the development of novel anti-pathogen therapies. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/62068 |
DOI: | 10.2174/1389450116666150416120559 |
ISSN: | 1389-4501 |
e-ISSN: | 1873-5592 |
Versão da editora: | http://www.eurekaselect.com/130416/article |
Arbitragem científica: | yes |
Acesso: | Acesso restrito autor |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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0010J.pdf Acesso restrito! | 1,21 MB | Adobe PDF | Ver/Abrir |