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https://hdl.handle.net/1822/65968
Título: | Controllable synthesis of biomimetic nano/submicro-fibrous tubes for potential small-diameter vascular grafts |
Autor(es): | Wan, Yizao Yang, Shanshan Peng, Mengxia Gama, F. M. Yang, Zhiwei Deng, Xiaoyan Zhou, Jianye Ouyang, Chenxi Luo, Honglin |
Data: | 3-Jun-2020 |
Editora: | RSC |
Revista: | Journal of Materials Chemistry B |
Citação: | Wan, Yizao; Yang, Shanshan; Peng, Mengxia; Gama, F. M.; Yang, Zhiwei; Deng, Xiaoyan; Zhou, Jianye; Ouyang, Chenxi; Luo, Honglin, Controllable synthesis of biomimetic nano/submicro-fibrous tubes for potential small-diameter vascular grafts. Journal of Materials Chemistry B, 8, 5694-5706, 2020 |
Resumo(s): | Mimicking the morphological structure of native blood vessels is critical for the development of vascular grafts. Herein, small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA) were fabricated via a combined electrospinning and step-by-step in situ biosynthesis. Scanning electron microscopy (SEM) observation shows the nano/submicro-fibrous morphology and well-interconnected porous structure of the BC/CA grafts. It is found that the BC/CA graft with a suitable BC content demonstrates lower potential of thrombus formation and enhanced endothelialization as compared to the BC and CA counterparts. Western blotting and RT-qPCR results suggest that the BC/CA-2 graft promotes endothelialization by improving expressions of genes vWF-1 and CD31 and protein CD31. The in vivo tests demonstrate much lower inflammatory response to the BC/CA graft. These results suggest that the BC/CA graft shows a great potential as an artificial graft for rapid formation of an endothelial cell monolayer. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/65968 |
DOI: | 10.1039/D0TB01002B |
ISSN: | 2050-750X |
e-ISSN: | 2050-7518 |
Versão da editora: | https://pubs.rsc.org/en/content/articlehtml/2020/tb/d0tb01002b |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_53762_1.pdf | 2,24 MB | Adobe PDF | Ver/Abrir |