Synthesis and in vitro activity of 6-amino-2,9-diarylpurines for Mycobacterium tuberculosis

doi:10.1016/j.tet.2009.06.065

Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/72847

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Campo DC	Valor	Idioma
dc.contributor.author	Correia, Carla	por
dc.contributor.author	Carvalho, M. Alice	por
dc.contributor.author	Proença, M. Fernanda R. P.	por
dc.date.accessioned	2021-05-25T15:44:29Z	-
dc.date.issued	2009-08-22	-
dc.date.submitted	2009-05	-
dc.identifier.citation	Correia, C., Carvalho, M. A., Proença, M. F. (2009). Synthesis and in vitro activity of 6-amino-2, 9-diarylpurines for Mycobacterium tuberculosis. Tetrahedron, 65(34), 6903-6911	por
dc.identifier.issn	0040-4020	por
dc.identifier.uri	https://hdl.handle.net/1822/72847	-
dc.description.abstract	A mild method was developed to synthesize 6-amino-2-phenolic-9-alkyl and 9-arylpurines. The new compounds were screened for antibacterial activity against Mycobacterium tuberculosis strain H(37)Rv. The 9-tolyl derivatives with a dimethylamino or a piperidine substituent in C6 and the 3-hydroxyphenyl or 4-hydroxyphenyl substituent in C2 were highly active against the bacilli. (C) 2009 Elsevier Ltd. All rights reserved.	por
dc.description.sponsorship	Antimycobacterial data were provided by the Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF) through a research and development contract with the US National Institute of Allergy and Infectious Diseases. The authors gratefully acknowledge the financial support by Universidade do Minho, Centro de Quimica and Fundacao para a Ciencia e Tecnologia (project PPCDT/QUI/59356/2004 and a PhD grant to C.C. SFRH/BD/22270/2005).	por
dc.language.iso	eng	por
dc.publisher	PERGAMON-ELSEVIER SCIENCE LTD	por
dc.rights	closedAccess	por
dc.subject	Purine	por
dc.subject	Antimicrobial agent	por
dc.subject	Tuberculosis	por
dc.title	Synthesis and in vitro activity of 6-amino-2,9-diarylpurines for Mycobacterium tuberculosis	por
dc.type	article	-
dc.peerreviewed	yes	por
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S0040402009009247	por
oaire.citationStartPage	6903	por
oaire.citationEndPage	6911	por
oaire.citationIssue	34	por
oaire.citationVolume	65	por
dc.date.updated	2021-05-21T08:43:15Z	-
dc.identifier.doi	10.1016/j.tet.2009.06.065	por
dc.date.embargo	10000-01-01	-
dc.subject.fos	Ciências Médicas::Medicina Básica	por
dc.subject.fos	Ciências Naturais::Ciências Químicas	por
dc.subject.wos	Science & Technology	-
sdum.export.identifier	10756	-
sdum.journal	Tetrahedron	por
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