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https://hdl.handle.net/1822/72847| Título: | Synthesis and in vitro activity of 6-amino-2,9-diarylpurines for Mycobacterium tuberculosis |
| Autor(es): | Correia, Carla Carvalho, M. Alice Proença, M. Fernanda R. P. |
| Palavras-chave: | Purine Antimicrobial agent Tuberculosis |
| Data: | 22-Ago-2009 |
| Editora: | PERGAMON-ELSEVIER SCIENCE LTD |
| Revista: | Tetrahedron |
| Citação: | Correia, C., Carvalho, M. A., Proença, M. F. (2009). Synthesis and in vitro activity of 6-amino-2, 9-diarylpurines for Mycobacterium tuberculosis. Tetrahedron, 65(34), 6903-6911 |
| Resumo(s): | A mild method was developed to synthesize 6-amino-2-phenolic-9-alkyl and 9-arylpurines. The new compounds were screened for antibacterial activity against Mycobacterium tuberculosis strain H(37)Rv. The 9-tolyl derivatives with a dimethylamino or a piperidine substituent in C6 and the 3-hydroxyphenyl or 4-hydroxyphenyl substituent in C2 were highly active against the bacilli. (C) 2009 Elsevier Ltd. All rights reserved. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/72847 |
| DOI: | 10.1016/j.tet.2009.06.065 |
| ISSN: | 0040-4020 |
| Versão da editora: | https://www.sciencedirect.com/science/article/pii/S0040402009009247 |
| Arbitragem científica: | yes |
| Acesso: | Acesso restrito autor |
| Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| 2009T6903.pdf Acesso restrito! | 264,54 kB | Adobe PDF | Ver/Abrir |
