Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/80295
Título: | Selective cytotoxicity of Portuguese propolis ethyl acetate fraction towards renal cancer cells |
Autor(es): | Freitas, Ana Sofia Costa, Marta Sílvia Freitas Pontes, Olívia Seidel, Veronique Proença, M. Fernanda R. P. Cardoso, Susana M. Oliveira, Rui Pedro Soares de Baltazar, Fátima Almeida Aguiar, Cristina |
Palavras-chave: | Propolis Fractionation Phenolic compounds Pectolinarigenin Cytotoxic activity Renal cell carcinoma |
Data: | 22-Jun-2022 |
Editora: | Multidisciplinary Digital Publishing Institute (MDPI) |
Revista: | Molecules |
Citação: | Freitas, A.S.; Costa, M.; Pontes, O.; Seidel, V.; Proença, F.; Cardoso, S.M.; Oliveira, R.; Baltazar, F.; Almeida-Aguiar, C. Selective Cytotoxicity of Portuguese Propolis Ethyl Acetate Fraction towards Renal Cancer Cells. Molecules 2022, 27, 4001. https://doi.org/10.3390/molecules27134001 |
Resumo(s): | Renal cell carcinoma is the most lethal cancer of the urological system due to late diagnosis and treatment resistance. Propolis, a beehive product, is a valuable natural source of compounds with bioactivities and may be a beneficial addition to current anticancer treatments. A Portuguese propolis sample, its fractions (<i>n</i>-hexane, ethyl acetate, <i>n</i>-butanol and water) and three subfractions (<b>P1</b>–<b>P3</b>), were tested for their toxicity on A498, 786-O and Caki-2 renal cell carcinoma cell lines and the non-neoplastic HK2 kidney cells. The ethyl acetate fraction showed the strongest toxicity against A498 (IC<sub>50</sub> = 0.162 µg mL<sup>−1</sup>) and 786-O (IC<sub>50</sub> = 0.271 µg mL<sup>−1</sup>) cells. With similar toxicity against 786-O, <b>P1</b> (IC<sub>50</sub> = 3.8 µg mL<sup>−1</sup>) and <b>P3</b> (IC<sub>50</sub> = 3.1 µg mL<sup>−1</sup>) exhibited greater effect when combined (IC<sub>50</sub> = 2.5 µg mL<sup>−1</sup>). Results support the potential of propolis and its constituents as promising coadjuvants in renal cell carcinoma treatment. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/80295 |
DOI: | 10.3390/molecules27134001 |
e-ISSN: | 1420-3049 |
Versão da editora: | https://www.mdpi.com/1420-3049/27/13/4001 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals CBMA - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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molecules-27-04001-v2.pdf | 1,52 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons