Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat

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dc.contributor.authorAnsah, Osei B.
dc.contributor.authorBourbia, Nora
dc.contributor.authorGonçalves, Leonor
dc.contributor.authorAlmeida, Armando
dc.contributor.authorPertovaara, Antti
dc.date.accessioned2014-07-07T13:25:25Z
dc.date.available2014-07-07T13:25:25Z
dc.date.issued2010
dc.date.submitted2009
dc.date.updated2014-06-11T14:53:23Z
dc.description.abstractThe role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous activation of amygdaloid group I metabotropic GluRs, mGluR(1) and mGluR(5), and the NMDA-R contributes to maintenance of sensory and emotional components of neuropathic pain. The predominant effect by amygdaloid group I mGluRs was facilitation of emotional-like pain behavior.por
dc.description.sponsorshipThis study was supported by the Academy of Finland, Helsinki, Finland, the Sigrid Juselius Foundation, Helsinki, Finland, the Center for International Mobility (CIMO), Helsinki, Finland, the Portuguese Foundation for Science and Technology, Lisbon, Portugal, and the Gulbenkian Foundation, Lisbon, Portugal.por
dc.distributioninternationalpor
dc.identifier.doi10.1016/j.bbr.2010.01.021
dc.identifier.issn0166-4328por
dc.identifier.pmid20097232por
dc.identifier.urihttps://hdl.handle.net/1822/29554
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0166432810000458por
dc.rightsopenAccesspor
dc.subjectAmygdalpor
dc.subjectAversive place-conditioningpor
dc.subjectDescending pain modulationpor
dc.subjectEmotional painpor
dc.subjectMechanical pain sensibilitypor
dc.subjectPeripheral neuropathypor
dc.subjectAmygdalapor
dc.subject.wosScience & Technologypor
dc.titleInfluence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic ratpor
dc.typearticle
dspace.entity.typePublicationen
oaire.citationEndPage178por
oaire.citationIssue1por
oaire.citationStartPage174por
oaire.citationTitleBehavioural Brain Researchpor
oaire.citationVolume209por
sdum.journalBehavioural Brain Researchpor
sdum.publicationstatuspublishedpor

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