The Barretos Cancer Hospital Animal Facility: implementation and results of a dedicated platform for preclinical oncology models

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dc.contributor.authorTeixeira, Silvia A.por
dc.contributor.authorLuzzi, Mayara de Cassiapor
dc.contributor.authorMartin, Ana Carolina Baptista Morenopor
dc.contributor.authorDuarte, Terence Teixeirapor
dc.contributor.authorLeal, Mônica de Oliveirapor
dc.contributor.authorTeixeira, Gustavo Ramospor
dc.contributor.authorReis, Monise Tadinpor
dc.contributor.authorJunior, Carlos Roberto Almeidapor
dc.contributor.authorSantos, Karinapor
dc.contributor.authorMelendez, Matias Eliseopor
dc.contributor.authorSilva, Diego da Cunha Silveira Alves dapor
dc.contributor.authorBernécule, Priscila Nevespor
dc.contributor.authorFirmino, Higor Vinicius Lourençopor
dc.contributor.authorAlves, Ana Laura Vieirapor
dc.contributor.authorGuimarães, Denise Peixotopor
dc.contributor.authorBorduqui, João Vitorpor
dc.contributor.authorLaus, Ana Carolinapor
dc.contributor.authorMançano, Bruna Minnitipor
dc.contributor.authorReis, R. M.por
dc.date.accessioned2022-12-21T09:57:49Z
dc.date.available2022-12-21T09:57:49Z
dc.date.issued2022-11-16
dc.date.updated2022-11-24T14:43:42Z
dc.description.abstractThe Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, focusing on mutant strains of mice (PTCH-knockout and <i>Apc<sup>Min</sup></i> mice), xenograft models, and patient-derived xenografts (PDXs). Our results show the progress and challenges in establishing these models and the need for having an appropriate representation of our cancer population to better understand tumor biology and to identify cancer biomarkers, which could be putatively targeted, allowing for personalized therapy.por
dc.description.sponsorshipThis study was funded by the Public Ministry of Labor Campinas (Research, Prevention and Education of Occupational Cancer) and by Pio XII Foundation, Barretos Cancer Hospital internal funds, Grant Number: 13/2021.por
dc.distributioninternationalpor
dc.identifier.citationTeixeira, S.A.; Luzzi, M.d.C.; Martin, A.C.B.M.; Duarte, T.T.; Leal, M.d.O.; Teixeira, G.R.; Reis, M.T.; Junior, C.R.A.; Santos, K.; Melendez, M.E.; Silva, D.d.C.S.A.d.; Bernécule, P.N.; Firmino, H.V.L.; Alves, A.L.V.; Guimarães, D.P.; Borduqui, J.V.; Laus, A.C.; Mançano, B.M.; Reis, R.M. The Barretos Cancer Hospital Animal Facility: Implementation and Results of a Dedicated Platform for Preclinical Oncology Models. Vet. Sci. 2022, 9, 636. https://doi.org/10.3390/vetsci9110636por
dc.identifier.doi10.3390/vetsci9110636por
dc.identifier.eissn2306-7381
dc.identifier.urihttps://hdl.handle.net/1822/81321
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherMultidisciplinary Digital Publishing Institutepor
dc.relation.publisherversionhttps://www.mdpi.com/2306-7381/9/11/636por
dc.rightsopenAccesspor
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/por
dc.subjectPTCH1-knockoutpor
dc.subjectApc<sup>Min</sup>por
dc.subjectxenograftspor
dc.subjectPDXpor
dc.subjectgenetically engineered mouse modelspor
dc.subjectpersonalized therapypor
dc.subjecttumor biologypor
dc.subjectApc(Min)por
dc.subject.fosCiências Médicas::Outras Ciências Médicaspor
dc.subject.wosScience & Technologypor
dc.titleThe Barretos Cancer Hospital Animal Facility: implementation and results of a dedicated platform for preclinical oncology modelspor
dc.typearticlepor
dspace.entity.typePublicationen
oaire.citationIssue11por
oaire.citationVolume9por
oaire.versionVoRpor
sdum.journalVeterinary Sciencespor

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