Thymbra capitata essential oil as potential therapeutic agent against Gardnerella vaginalis biofilm-related infections

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dc.commentsCEB46735por
dc.contributor.authorMachado, Danielapor
dc.contributor.authorGaspar, Carlospor
dc.contributor.authorPalmeira-de-Oliveira, Anapor
dc.contributor.authorCavaleiro, Carlospor
dc.contributor.authorSalgueiro, Lígiapor
dc.contributor.authorMartinez-de-Oliveira, Josépor
dc.contributor.authorCerca, Nunopor
dc.date.accessioned2017-10-23T10:46:18Z
dc.date.issued2017-04
dc.date.updated2017-08-03T11:08:45Z
dc.description.abstractAim: To evaluate the antibacterial activity of Thymbra capitata essential oil and its main compound, carvacrol, against Gardnerella vaginalis grown planktonically and as biofilms, and its effect of vaginal lactobacilli. Materials & methods: Minimal inhibitory concentration, minimal lethal concentration determination and flow cytometry analysis were used to assess the antibacterial effect against planktonic cells. Antibiofilm activity was measured through quantification of biomass and visualization of biofilm structure by confocal laser scanning microscopy. Results: T. capitata essential oil and carvacrol exhibited a potent antibacterial activity against G. vaginalis cells. Antibiofilm activity was more evident with the essential oil than carvacrol. Furthermore, vaginal lactobacilli were significantly more tolerant to the essential oil. Conclusion: T. capitata essential oil stands up as a promising therapeutic agent against G. vaginalis biofilm-related infections.por
dc.description.publicationversioninfo:eu-repo/semantics/publishedVersionpor
dc.description.sponsorshipThe authors are grateful to Foundation for Science and Technology (FCT, Portugal) for D Machado grant (SFRH/ BD/87569/2012) and financial support (FCT Strategic Project of UID/BIO/04469/2013 unit). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.por
dc.distributioninternationalpor
dc.identifier.citationMachado, Daniela; Gaspar, Carlos; Palmeira-de-Oliveira, Ana; Cavaleiro, Carlos; Salgueiro, Lígia; Martinez-de-Oliveira, José; Cerca, Nuno, Thymbra capitata essential oil as potential therapeutic agent against Gardnerella vaginalis biofilm-related infections. Future Microbiology, 12(5), 407-416, 2017por
dc.identifier.doi10.2217/fmb-2016-0184por
dc.identifier.eissn1746-0921por
dc.identifier.issn1746-0913por
dc.identifier.pmid28339292por
dc.identifier.urihttps://hdl.handle.net/1822/46748
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherFuture Medicinepor
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F87569%2F2012/PTpor
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147337/PTpor
dc.relation.publisherversionhttp://www.futuremedicine.com/loi/fmbpor
dc.rightsrestrictedAccesspor
dc.subjectbacterial vaginosispor
dc.subjectbiofilmspor
dc.subjectcarvacrolpor
dc.subjectGardnerella vaginalispor
dc.subjectlactobacillipor
dc.subjectThymbra capitata essential oilpor
dc.subject.wosScience & Technologypor
dc.titleThymbra capitata essential oil as potential therapeutic agent against Gardnerella vaginalis biofilm-related infectionspor
dc.typearticle
dspace.entity.typePublicationen
oaire.citationConferencePlaceUnited Kingdom
oaire.citationEndPage416por
oaire.citationIssue5por
oaire.citationStartPage407por
oaire.citationVolume12por
sdum.journalFuture Microbiologypor

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