Low energy nanoemulsions as a carrier of thyme and lemon balm essential oils

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dc.contributor.authorSampaio, Cátia I.por
dc.contributor.authorBourbon, Ana Isabel Juncá Sottomayor Lisboapor
dc.contributor.authorGonçalves, Catarinapor
dc.contributor.authorPastrana, Lorenzo M.por
dc.contributor.authorDias, Alicepor
dc.contributor.authorCerqueira, Miguel Ângelo Parente Ribeiropor
dc.date.accessioned2024-03-12T09:35:52Z
dc.date.available2024-03-12T09:35:52Z
dc.date.issued2022-01-15
dc.description.abstractThe aim of this work was to produce monomodal and stable thyme and lemon balm-loaded nanoemulsions (NE), through a low energy approach. NEs were prepared by the emulsion phase inversion method using sunflower oil as carrier and Tween 80 as surfactant. Different surfactant-to-oil ratios (SOR) and essential oil (EO) loadings were evaluated. Nanoemulsions presented a monomodal diameter distribution below 200 nm and high negative zeta potential (>-40 mV). Nanoemulsions loaded with EOs were physically stable for 3 months at 4 degrees C and 20 degrees C. Nanoemulsions with thyme EO presented the highest radical scavenging activity by DPPH and ABTS tests. Loaded nanoemulsions were not effective against Escherichia coli but could inhibit Staphylococcus aureus. Cytotoxicity studies using cell counting kit-8 and resazurin assays revealed a dose-responsive effect of nanoemulsions on Caco-2 cells after incubation for 24 h. A concentration of 100 mu g oil/mL of NE for unloaded and thyme loaded and 50 mu g oil/mL of NE for lemon balm loaded showed to be safe to use.por
dc.description.sponsorshipThis research received funding from the H2020 research and inno-vation programme under the Marie Sklodowska-Curie grant agreement No 778388 (H2020 MSCA-RISE-2017, FODIAC) , and MICRODIGEST project (grant agreement 037716) co-funded by FCT and ERDF through COMPETE2020. We would like to thank the Earth Essences for its kind supply of essential oils.por
dc.distributioninternationalpor
dc.identifier.citationSampaio, C. I., Bourbon, A. I., Gonçalves, C., Pastrana, L. M., Dias, A. M., & Cerqueira, M. A. (2022, January). Low energy nanoemulsions as carriers of thyme and lemon balm essential oils. Lwt. Elsevier BV. http://doi.org/10.1016/j.lwt.2021.112748
dc.identifier.doi10.1016/j.lwt.2021.112748por
dc.identifier.issn0023-6438por
dc.identifier.urihttps://hdl.handle.net/1822/89419
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/778388/EUpor
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0023643821019010por
dc.rightsopenAccesspor
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/por
dc.subjectLemon balm oilpor
dc.subjectLow energy emulsificationpor
dc.subjectThyme oilpor
dc.subjectNanoencapsulationpor
dc.subject.fosCiências Naturais::Ciências Químicaspor
dc.subject.odsProteger a vida terrestrepor
dc.subject.wosScience & Technologypor
dc.titleLow energy nanoemulsions as a carrier of thyme and lemon balm essential oilspor
dc.typearticlepor
dspace.entity.typePublicationen
oaire.citationVolume154por
oaire.versionAOpor
sdum.journalLWT - Food Science and Technologypor

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