Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortium

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dc.contributor.authorReis, R. M.por
dc.contributor.authorCampa, Danielrpor
dc.contributor.authorMartino, Alessandropor
dc.contributor.authorSainz, Juanpor
dc.contributor.authorBuda, Gabrielepor
dc.contributor.authorJamroziak, Krzysztofpor
dc.contributor.authorWeinhold, Nielspor
dc.contributor.authorGarcía-Sanz, Ramónpor
dc.contributor.authorJurado, Manuelpor
dc.contributor.authorRíos, Rafaelpor
dc.contributor.authorSzemraj-Rogucka, Zofiapor
dc.contributor.authorMarques, Herlanderpor
dc.contributor.authorLesueur, Fabiennepor
dc.contributor.authorBugert, Peterpor
dc.contributor.authorMoreno, Victorpor
dc.contributor.authorSzemraj, Januszpor
dc.contributor.authorOrciuolo, Enricopor
dc.contributor.authorGemignani, Federicapor
dc.contributor.authorPetrini, Mariopor
dc.contributor.authorGoldschmidt, Hartmutpor
dc.contributor.authorLandi, Stefanopor
dc.contributor.authorCanzian, Federicopor
dc.date.accessioned2015-02-05T12:39:52Z
dc.date.available2015-02-05T12:39:52Z
dc.date.issued2012-05
dc.date.updated2015-01-30T16:29:34Z
dc.description.abstractGenome-wide association studies (GWAS) have shown that the 8q24 region harbours multiple independent cancer susceptibility loci, even though it is devoid of genes. Given that no GWAS data are currently available for multiple myeloma (MM), we tested the hypothesis that genetic variants in this region could play a role in MM risk. We genotyped 20 single nucleotide polymorphisms of 8q24 in 1188 MM cases and 2465 controls and found a statistically significant (P = 0·0022) association between rs2456449 and MM risk. These data provide further evidence that the genetic variability in the 8q24 region is associated with cancer risk, particularly haematological malignancies.por
dc.description.sponsorshipCollection of blood samples from Spain patients from Granada area and DNA extraction was partially supported by grants P08-CVI-4116 from Consejeria de Salud de la Junta de Andalucia (Sevilla, Spain) and PI081051 from Fondo de Investigaciones Sanitarias (Madrid, Spain). Collection of blood samples from Polish patients and controls from Lodz area and DNA extraction was supported by a grant from Polish Ministry of Science and Higher Education (No. NN402178334).por
dc.distributioninternationalpor
dc.identifier.doi10.1111/j.1365-2141.2012.09047.xpor
dc.identifier.issn0007-1048por
dc.identifier.pmid22590720por
dc.identifier.urihttps://hdl.handle.net/1822/33602
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherBlackwell Publishingpor
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2012.09047.x/pdfpor
dc.rightsrestrictedAccesspor
dc.subjectGeneticspor
dc.subjectCancer geneticspor
dc.subjectCancerpor
dc.subjectEpidemiologypor
dc.subjectHaematological malignanciespor
dc.subjectMyelomapor
dc.subject.wosScience & Technologypor
dc.titleComprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortiumpor
dc.typearticle
dspace.entity.typePublicationen
oaire.citationEndPage338por
oaire.citationIssue3por
oaire.citationStartPage331por
oaire.citationTitleBritish Journal of Haematologypor
oaire.citationVolume157por
sdum.journalBritish Journal of Haematologypor
sdum.publicationstatuspublishedpor

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