Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy

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dc.contributor.authorSilva, M.por
dc.contributor.authorFerreira, P. E.por
dc.contributor.authorOtienoburu, S. D.por
dc.contributor.authorCalçada, Carla Sofia Martinspor
dc.contributor.authorNgasala, B.por
dc.contributor.authorBjörkman, A.por
dc.contributor.authorMårtensson, A.por
dc.contributor.authorGil, J. P.por
dc.contributor.authorVeiga, Maria Isabel Mendespor
dc.date.accessioned2019-11-21T15:10:59Z
dc.date.available2020-07-01T06:00:18Z
dc.date.issued2019
dc.description.abstractDelayed parasite clearance and, consequently, reduced efficacy of artemisinin-based combination therapies have been linked with Plasmodium falciparum K13 gene SNPs in Southeast Asia. In Africa, significantly prolonged clearance has not yet been observed and the presently restricted variation in parasite clearance cannot be explained by K13 polymorphisms.por
dc.description.sponsorshipSwedish Research Council (VR-2014-3134); the Swedish International Development Cooperation Agency(SWE-200-165); the Northern Portugal Regional Operational Programme(NORTE 2020), under the Portugal 2020 Partnership Agreement, throughthe European Regional Development Fund (NORTE-01-0145-FEDER-000013); and the Fundac ̧~ao para a Cieˆ ncia e Tecnologia (FCT) (SFRH/BD/129769/2017 to M. S., IF/00143/2015 to P. E. F., PD/BD/127826/2016 toC. C. and SFRH/BPD/76614/2011 to M. I. V.por
dc.distributioninternationalpor
dc.identifier.citationSilva, M., Ferreira, P. E., Otienoburu, S. D., Calçada, C., et. al. (2019). Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy. Journal of Antimicrobial Chemotherapy, 74(7), 1890-1893por
dc.identifier.doi10.1093/jac/dkz098por
dc.identifier.eissn1460-2091
dc.identifier.issn0305-7453
dc.identifier.pmid30869127por
dc.identifier.urihttps://hdl.handle.net/1822/62313
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherOxford University Presspor
dc.relationinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F129769%2F2017/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00143%2F2015%2FCP1294%2FCT0001/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/POR_NORTE/PD%2FBD%2F127826%2F2016/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBPD%2F76614%2F2011/PT
dc.relation.publisherversionhttps://academic.oup.com/jac/article-abstract/74/7/1890/5380571por
dc.rightsopenAccesspor
dc.subject.fosCiências Médicas::Medicina Básicapor
dc.subject.wosScience & Technologypor
dc.titlePlasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapypor
dc.typearticlepor
dspace.entity.typePublicationen
oaire.citationEndPage1893por
oaire.citationIssue7por
oaire.citationStartPage1890por
oaire.citationVolume74por
sdum.journalJournal of Antimicrobial Chemotherapypor

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