Emerging scaffold‑ and cellular‑based strategies for brain tissue regeneration and imaging

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dc.commentshttp://3bs.uminho.pt/node/20745por
dc.contributor.authorCollins, Maurice N.por
dc.contributor.authorZamboni, Fernandapor
dc.contributor.authorSerafin, Aleksandrapor
dc.contributor.authorEscobar, Anepor
dc.contributor.authorStepanian, Romainpor
dc.contributor.authorCulebras, Mariopor
dc.contributor.authorReis, R. L.por
dc.contributor.authorOliveira, J. M.por
dc.date.accessioned2022-03-18T12:30:51Z
dc.date.available2022-03-18T12:30:51Z
dc.date.issued2022-03
dc.date.submitted2022-03
dc.date.updated2022-03-18T09:56:49Z
dc.description.abstractStimulating brain tissue regeneration is a major challenge after central nervous system (CNS) injury, such as those observed from trauma or cerebrovascular accidents. Full regeneration is difficult even when a neurogenesis-associated repair response may occur. Currently, there are no effective treatments to stimulate brain tissue regeneration. However, biomaterial scaffolds are showing promising results, where hydrogels are the materials of choice to develop these supportive scaffolds for cell carriers. Their combination with growth factors, such as brain-derived neurotrophic factor (BDNF), basic fibroblast growth factor (bFGF), or vascular endothelial growth factor (VEGF), together with other cell therapy strategies allows the prevention of further neuronal death and can potentially lead to the direct stimulation of neurogenesis and vascularisation at the injured site. Imaging of the injured site is particularly critical to study the reestablishment of neural cell functionality after brain tissue injury. This review outlines the latest key advances associated with different strategies aiming to promote the neuroregeneration, imaging, and functional recovery of brain tissue.por
dc.description.sponsorshipThe authors thank the fnancial support from the Portuguese Foundation for Science and Technology for the funds provided under the project NanOptoNerv (ref. PTDC/NAN-MAT/29936/2017) and to INTERREG V A España Portugal (POCTEP) under the project 2IQBIONEURO (ref. 0624_2IQBIONEURO_6_E). The authors would like to thank the funding provided by the Irish Research Council through the IRC Postdoctoral Fellowship (GOIPG/2021/75) for FZ and through the IRC Enterprise Partnership Scheme with Johnson and Johnson (EPSPG/2020/78) for ASpor
dc.distributioninternationalpor
dc.identifier.citationCollins M. N., Zamboni F., Serafin A., Escobar A., Stepanian R., Culebras M., Reis R. L., Oliveira J. M. Emerging scaffold‑ and cellular‑based strategies for brain tissue regeneration and imaging, In vitro models, doi:10.1007/s44164-022-00013-0, 2022por
dc.identifier.doi10.1007/s44164-022-00013-0por
dc.identifier.issn2731-3441por
dc.identifier.urihttps://hdl.handle.net/1822/76573
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSpringer Naturepor
dc.relationinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FNAN-MAT%2F29936%2F2017/PTpor
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s44164-022-00013-0por
dc.rightsopenAccesspor
dc.subjectBrainpor
dc.subjectScaffoldspor
dc.subjectTissue engineeringpor
dc.subjectCentral nervous systempor
dc.subjectBiomaterialspor
dc.subjectCarrierspor
dc.subjectCellspor
dc.subjectImagingpor
dc.subjectGrowth factorspor
dc.subjectTissue regenerationpor
dc.titleEmerging scaffold‑ and cellular‑based strategies for brain tissue regeneration and imagingpor
dc.typearticle
dspace.entity.typePublicationen
oaire.citationEndPage150por
oaire.citationIssue2por
oaire.citationStartPage129por
oaire.citationVolume1por
sdum.journalIn vitro modelspor

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