In vitro and computational studies of transdermal perfusion of nanoformulations containing a large molecular weight protein

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dc.contributor.authorMartins, Margarida Isabel Barros Coelho
dc.contributor.authorAzóia, Nuno G.
dc.contributor.authorRibeiro, Artur J.
dc.contributor.authorShimanovich, Ulyana
dc.contributor.authorSilva, Carla Manuela Pereira Marinho da
dc.contributor.authorPaulo, Artur Cavaco
dc.date.accessioned2013-06-05T17:15:15Z
dc.date.available2013-06-05T17:15:15Z
dc.date.issued2013
dc.description.abstractTransdermal perfusion of a large protein is reported for the first time, using a nanoemulsion of bovine serum albumin (66 kDa) of 160 nm prepared by a solid-in-oil (S/O) process. Molecular dynamics simulations confirmed skin permeation by these formulations, with integration of the protein into the lipid bilayers. These results demonstrate the real possibility of delivering large proteins transdermally for a range of medical and cosmetic applications.por
dc.description.sponsorshipWe thank Matadouro - Central Carnes de Entre Douro e Minho, Lda for their support on pig samples. The histological studies were supported by the Department of Histology from Life and Health Sciences Research Institute (ICVS), University of Minho. The confocal 3D images were performed by Department of Chemistry and Kanbar Laboratory for Nanomaterials Bar-Ilan University Center for Advanced Materials and Nanotechnology. Carla Silva would like to thanks Fundacao para a Ciencia e a Tecnologia for their funding (SFRH/BPD/46515/2008).por
dc.distributioninternationalpor
dc.identifier.citationMartins, M., Azoia, N. G., Ribeiro, A., Shimanovich, U., Silva, C., & Cavaco-Paulo, A. (2013). In vitro and computational studies of transdermal perfusion of nanoformulations containing a large molecular weight protein. Em Colloids and Surfaces B: Biointerfaces (Vol. 108, pp. 271–278). Elsevier BV. https://doi.org/10.1016/j.colsurfb.2013.02.032
dc.identifier.doi10.1016/j.colsurfb.2013.02.032por
dc.identifier.issn0927-7765por
dc.identifier.pmid23563294por
dc.identifier.urihttps://hdl.handle.net/1822/24342
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevier Sciencepor
dc.publisher.uriElsevier BVpor
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0927776513001616por
dc.rightsopenAccesspor
dc.subjectProteinpor
dc.subjectSurfactantpor
dc.subjectNanodispersionpor
dc.subjectTransdermal perfusionpor
dc.subjectHydrophilic macromoleculespor
dc.subject.wosScience & Technologypor
dc.titleIn vitro and computational studies of transdermal perfusion of nanoformulations containing a large molecular weight proteineng
dc.typearticlepor
dspace.entity.typePublicationen
oaire.citationEndPage278por
oaire.citationStartPage271por
oaire.citationTitleColloids and Surfaces B: Biointerfacespor
oaire.citationVolume108por
sdum.journalColloids and Surfaces B: Biointerfacespor
sdum.publicationstatuspublishedpor

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