Dynamic piezoelectric stimulation enhances osteogenic differentiation of human adipose stem cells

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dc.contributor.authorRibeiro, Clarisse Marta Oliveirapor
dc.contributor.authorPärssinen, J.por
dc.contributor.authorSencadas, Vítor João Gomes Silvapor
dc.contributor.authorCorreia, Vítor Manuel Gomespor
dc.contributor.authorMiettinen, S.por
dc.contributor.authorHytönen, V. P.por
dc.contributor.authorLanceros-Méndez, S.por
dc.date.accessioned2015-12-10T14:51:31Z
dc.date.issued2015
dc.description.abstractThis work reports on the influence of the substrate polarization of electroactive β-PVDF on human adipose stem cells (hASCs) differentiation under static and dynamic conditions. hASCs were cultured on different β-PVDF surfaces (non-poled and “poled -”) adsorbed with fibronectin and osteogenic differentiation was determined using a quantitative alkaline phosphatase assay. “Poled -” β-PVDF samples promote higher osteogenic differentiation, which is even higher under dynamic conditions. It is thus demonstrated that electroactive membranes can provide the necessary electromechanical stimuli for the differentiation of specific cells and therefore will support the design of suitable tissue engineering strategies, such as bone tissue engineering.por
dc.description.sponsorshipThis work is funded by FEDER funds through the "Programa Operacional Fatores de Competitividade – COMPETE" and by national funds arranged by FCT- Fundação para a Ciência e a Tecnologia, project references PTDC/CTM-NAN/112574/2009 and PEST-C/FIS/UI607/2014. The authors also thank funding from Matepro –Optimizing Materials and Processes”, ref. NORTE-07-0124-FEDER-000037”, co-funded by the “Programa Operacional Regional do Norte” (ON.2 – O Novo Norte), under the “Quadro de Referência Estratégico Nacional” (QREN), through the “Fundo Europeu de Desenvolvimento Regional” (FEDER). CR, VS and VC thank the FCT for the SFRH/BPD/90870/2012, SFRH/BPD/64958/2009 and SFRH/BPD/97739/2013 grants, respectively. Academy of Finland is acknowledged for research funding (projects 136288 (VH) and 256931 (JP)).por
dc.distributioninternationalpor
dc.identifier.doi10.1002/jbm.a.35368por
dc.identifier.issn1549-3296por
dc.identifier.issn1552-4965por
dc.identifier.pmid25370596por
dc.identifier.urihttps://hdl.handle.net/1822/38869
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWileypor
dc.relationinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/112574/PTpor
dc.relationinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/137353/PTpor
dc.relationSFRH/BPD/90870/2012,por
dc.relationSFRH/BPD/64958/2009por
dc.relationSFRH/BPD/97739/2013por
dc.rightsopenAccess
dc.subjectElectroactive polymerpor
dc.subjectStem cellpor
dc.subjectOsteogenesispor
dc.subjectDynamic conditionpor
dc.subjectdynamic conditionspor
dc.subject.fosCiências Naturais::Ciências Físicaspor
dc.subject.wosScience & Technologypor
dc.titleDynamic piezoelectric stimulation enhances osteogenic differentiation of human adipose stem cellspor
dc.typearticlepor
dspace.entity.typePublicationen
oaire.citationEndPage2175por
oaire.citationIssue6por
oaire.citationStartPage2172por
oaire.citationVolume103por
rcaap.embargofctlanceros@fisica.uminho.ptpor
sdum.journalJournal of Biomedical Materials Research: Part Apor
sdum.publicationstatuspublishedpor

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