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https://hdl.handle.net/1822/10497
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Campo DC | Valor | Idioma |
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dc.contributor.author | Gregory, Marslin | - |
dc.contributor.author | Vithalrao, K. P. | - |
dc.contributor.author | Gregory, Franklin | - |
dc.contributor.author | Kalaichelvan, V. K. | - |
dc.date.accessioned | 2010-03-19T15:07:15Z | - |
dc.date.available | 2010-03-19T15:07:15Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | "American Journal of Pharmacology and Toxicology". ISSN 1557-4962. 4:3 ( 2009) 89-93. | por |
dc.identifier.issn | 1557-4962 | por |
dc.identifier.uri | https://hdl.handle.net/1822/10497 | - |
dc.description.abstract | Problem statement: In spite of being one of the well-known medicinal plants used in Indian traditional medicine to treat several ailments, studies pertaining to the pharmacological properties of Ficus arnottiana are very scarce. We studied the anti-ulcer activity and acute toxicity of Ficus arnottiana leaf methanolic extract for the first time. Approach: Freshly collected F. arnottiana leaves were dried, powdered and extracted in methanol. To study the anti-ulcer activity, Wistar rats were orally administered with different doses of the extract (0, 250 and 500 mg kg-1 body weight day-1) or with the reference drug omeprazole (8 mg kg-1) for 10 days. After induction of ulcer using 5 mL kg-1 ethanol, stomachs of these animals were analyzed for gastric volume, ulcer area and gross pathological changes. Results: Our results showed that F. arnottiana methanolic extract could prevent ulcer in rats in a dose-dependent manner. Histological studies revealed that the extract had mucoprotective activity. The extract did not show any acute toxicity even at the dose of 5000 mg kg-1 indicating that the extract has no lethal effect. Preliminary phytochemical screening of this extract identified the presence of important secondary metabolites like flavonoids and tannins. Conclusion/Recommendations: From this study, it is clear that F. arnottiana leaf extract had significant anti-ulcer activity in animal models. It had muco-protective activity and gastric antisecretary activity. The extract is non-toxic even at relatively high concentrations. | por |
dc.description.sponsorship | (undefined) | por |
dc.language.iso | eng | por |
dc.rights | openAccess | por |
dc.subject | Ficus arnottiana | por |
dc.subject | Flavonoids | por |
dc.subject | Gastric volume | por |
dc.subject | Ulcer area | por |
dc.subject | Omeprazole | por |
dc.title | Anti-ulcer (ulcer-preventive) activity of ficus arnottiana miq. (moraceae) leaf methanolic extract | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | www.scipub.org | por |
sdum.number | 3 | por |
sdum.pagination | 89-93 | por |
sdum.publicationstatus | published | por |
sdum.volume | 4 | por |
oaire.citationStartPage | 89 | por |
oaire.citationEndPage | 93 | por |
oaire.citationIssue | 3 | por |
oaire.citationVolume | 4 | por |
dc.identifier.doi | 10.3844/ajptsp.2009.89.93 | por |
sdum.journal | American Journal of Pharmacology and Toxicology | por |
Aparece nas coleções: | DBio - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Marslin et al 2009 AJPT.pdf | Anti-Ulcer (Ulcer-Preventive) Activity of Ficus arnottiana Miq. (Moraceae) Leaf Methanolic Extract | 91,54 kB | Adobe PDF | Ver/Abrir |