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https://hdl.handle.net/1822/10497
Título: | Anti-ulcer (ulcer-preventive) activity of ficus arnottiana miq. (moraceae) leaf methanolic extract |
Autor(es): | Gregory, Marslin Vithalrao, K. P. Gregory, Franklin Kalaichelvan, V. K. |
Palavras-chave: | Ficus arnottiana Flavonoids Gastric volume Ulcer area Omeprazole |
Data: | 2009 |
Revista: | American Journal of Pharmacology and Toxicology |
Citação: | "American Journal of Pharmacology and Toxicology". ISSN 1557-4962. 4:3 ( 2009) 89-93. |
Resumo(s): | Problem statement: In spite of being one of the well-known medicinal plants used in Indian traditional medicine to treat several ailments, studies pertaining to the pharmacological properties of Ficus arnottiana are very scarce. We studied the anti-ulcer activity and acute toxicity of Ficus arnottiana leaf methanolic extract for the first time. Approach: Freshly collected F. arnottiana leaves were dried, powdered and extracted in methanol. To study the anti-ulcer activity, Wistar rats were orally administered with different doses of the extract (0, 250 and 500 mg kg-1 body weight day-1) or with the reference drug omeprazole (8 mg kg-1) for 10 days. After induction of ulcer using 5 mL kg-1 ethanol, stomachs of these animals were analyzed for gastric volume, ulcer area and gross pathological changes. Results: Our results showed that F. arnottiana methanolic extract could prevent ulcer in rats in a dose-dependent manner. Histological studies revealed that the extract had mucoprotective activity. The extract did not show any acute toxicity even at the dose of 5000 mg kg-1 indicating that the extract has no lethal effect. Preliminary phytochemical screening of this extract identified the presence of important secondary metabolites like flavonoids and tannins. Conclusion/Recommendations: From this study, it is clear that F. arnottiana leaf extract had significant anti-ulcer activity in animal models. It had muco-protective activity and gastric antisecretary activity. The extract is non-toxic even at relatively high concentrations. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/10497 |
DOI: | 10.3844/ajptsp.2009.89.93 |
ISSN: | 1557-4962 |
Versão da editora: | www.scipub.org |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | DBio - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Marslin et al 2009 AJPT.pdf | Anti-Ulcer (Ulcer-Preventive) Activity of Ficus arnottiana Miq. (Moraceae) Leaf Methanolic Extract | 91,54 kB | Adobe PDF | Ver/Abrir |