Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/18765
Título: | Direct intra-accumbal infusion of a beta-adrenergic receptor antagonist abolishes WIN 55,212-2-induced aversion |
Autor(es): | Carvalho, Ana Raquel Franky Gomes Bockstaele, Elisabeth J. Van |
Palavras-chave: | Cannabinoids Lithium Adrenergic receptors Place conditioning Aversion |
Data: | 2011 |
Editora: | Elsevier 1 |
Revista: | Neuroscience Letters |
Resumo(s): | The cannabinoid system is known to interact with a variety of neuromodulators in the central nervous system and impacts diverse behaviors. Previous studies have demonstrated that limbic norepinephrine is a critical determinant in the behavioral expression of cannabinoid-induced aversion. The present study was carried out to define the adrenergic receptor subtype involved in mediating cannabinoid-induced behavioral responses. An acute microinjection of the 1-adrenergic receptor blocker, betaxolol, directly into the nucleus accumbens (Acb), was able to prevent WIN 55,212-2-induced aversion, but not lithium-induced aversion, as measured in a place conditioning paradigm. These results suggest that noradrenergic transmission in the Acb is important for cannabinoid-induced aversion and that beta-adrenergic antagonists may be effective in counteracting negative side effects of cannabinoid-based agents. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/18765 |
DOI: | 10.1016/j.neulet.2011.06.008 |
ISSN: | 0304-3940 |
Versão da editora: | http://www.sciencedirect.com/science/article/pii/S0304394011009025 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Carvalho AF_Neurosc Lett-pp 2011.pdf | Versão preprint | 558,47 kB | Adobe PDF | Ver/Abrir |