Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/28455
Título: | Microtubule-associated protein tau is essential for long-term depression in the hippocampus |
Autor(es): | Kimura, Tetsuya Whitcomb, Daniel J. Jo, Jihoon Regan, Philip Piers, Thomas Heo, Seonghoo Brown, Christopher Hashikawa, Tsutomu Murayama, Miyuki Seok, Heon Sotiropoulos, I. Kim, Eunjoon Collingridge, Graham L. Takashima, Akihiko Cho, Kwangwook |
Palavras-chave: | Alzheimer's disease hippocampus synaptic plasticity long-term depression tau |
Data: | 2014 |
Editora: | Royal Society |
Revista: | Philosophical Transactions of the Royal Society B: Biological Sciences |
Resumo(s): | The microtubule-associated protein tau is a principal component of neurofibrillary tangles, and has been identified as a key molecule in Alzheimer's disease and other tauopathies. However, it is unknown how a protein that is primarily located in axons is involved in a disease that is believed to have a synaptic origin. To investigate a possible synaptic function of tau, we studied synaptic plasticity in the hippocampus and found a selective deficit in long-term depression (LTD) in tau knockout mice in vivo and in vitro, an effect that was replicated by RNAi knockdown of tau in vitro. We found that the induction of LTD is associated with the glycogen synthase kinase-3-mediated phosphorylation of tau. These observations demonstrate that tau has a critical physiological function in LTD. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/28455 |
DOI: | 10.1098/rstb.2013.0144 |
ISSN: | 0962-8436 |
Versão da editora: | http://rstb.royalsocietypublishing.org/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
kimura t_philos t r soc b 2014 posp.pdf | 996,65 kB | Adobe PDF | Ver/Abrir |