Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/48383
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Gomes, Ana L. | por |
dc.contributor.author | Bardales, Ricardo H. | por |
dc.contributor.author | Milanezi, Maria Fernanda Grillo | por |
dc.contributor.author | Reis, R. M. | por |
dc.contributor.author | Schmitt, Fernando | por |
dc.date.accessioned | 2017-12-18T11:28:11Z | - |
dc.date.available | 2017-12-18T11:28:11Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1943-7722 | - |
dc.identifier.uri | https://hdl.handle.net/1822/48383 | - |
dc.description.abstract | Gastrointestinal stromal tumors (GISTs) are characterized by overexpression and mutations of c-Kit. Approximately 80% of c-Kit mutations occur in exon H, being a response factor to imatinib (Gleevec) therapy. Mutations of platelet-derived growth factor receptor-a (PDGFRA) are observed in a subset of GISTs lacking c-Kit mutations. We aimed to assess whether c-Kit and PDGFRA mutation analysis of GISTs obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) could be routinely performed. Mutation analysis of c-Kit hotspot exons (9, 11, 13, and 17) and PDGFRA hotspot exons (12 and 18) was performed in aspirates of 33 GISTs and 18 non-GIST mesenchymal tumors. Of the GIST cases, 19 (58%) of 33 contained a mutation in exon 11, 1 (3%) in exon 9, and none in exons 13 and 17. No activating c-Kit mutations were identified in non-GIST cases. No PDGFRA mutation was detected. Mutation analysis is possible in these FNA cell blocks and can assist in the diagnosis and therapeutic decisions in GIST cases. | por |
dc.description.sponsorship | Supported in part by NOVARTIS Oncology | por |
dc.language.iso | eng | por |
dc.publisher | American Society for Clinical Pathologists (ASCP) | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBI%2F15257%2F2004/PT | por |
dc.rights | openAccess | por |
dc.subject | Endoscopic ultrasound-guided fine-needle aspiration | por |
dc.subject | c-Kit | por |
dc.subject | Platelet-derived growth factor-α | por |
dc.subject | PDGFRA | por |
dc.subject | Gastrointestinal stromal tumor | por |
dc.subject | GIST | por |
dc.subject | Mutations | por |
dc.title | Molecular analysis of c-Kit and PDGFRA in GISTs diagnosed by EUS | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://ajcp.ascpjournals.org/content/127/1/89.long | por |
oaire.citationStartPage | 89 | por |
oaire.citationEndPage | 96 | por |
oaire.citationIssue | 1 | por |
oaire.citationVolume | 127 | por |
dc.date.updated | 2017-12-18T10:03:38Z | - |
dc.identifier.eissn | 0002-9173 | - |
dc.identifier.doi | 10.1309/M1EC8JE9ACAMJACU | por |
dc.identifier.pmid | 17145623 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | American Journal of Clinical Pathology | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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gomes al_am j clin pathol 2007.pdf | 184,46 kB | Adobe PDF | Ver/Abrir |