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https://hdl.handle.net/1822/61457| Título: | T-1237C polymorphism of TLR9 gene is not associated with multiple sclerosis in the Portuguese population |
| Autor(es): | Carvalho, Agostinho Santos, M. Maciel, P. Rodrigues, Fernando José dos Santos |
| Palavras-chave: | Adult Age of Onset Female Genetic Predisposition to Disease Genotype Humans Male Middle Aged Multiple Sclerosis Portugal Promoter Regions, Genetic Severity of Illness Index Toll-Like Receptor 9 Polymorphism, Genetic Disease Inflammation Innate immunity Susceptibility toll-like receptor |
| Data: | Mai-2008 |
| Editora: | SAGE Publications |
| Revista: | Multiple Sclerosis |
| Resumo(s): | Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, with disturbances of the immunological balance. As TLR9-null mice showed increased resistance to experimental autoimmune encephalomyelitis and recent genetic investigations showed that T-1237C promoter polymorphism of TLR9, commonly implicated in autoimmune diseases, induces a deregulation of its expression, we performed an association study in a Portuguese population of 165 MS patients and unrelated healthy controls. Our results show no significant association with MS and no protective effect of T-1237C concerning age of onset, disease severity or disease subtype in MS patients. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/61457 |
| DOI: | 10.1177/1352458507084594 |
| ISSN: | 1352-4585 |
| e-ISSN: | 1477-0970 |
| Arbitragem científica: | yes |
| Acesso: | Acesso restrito autor |
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Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| carvalho2008 (1).pdf Acesso restrito! | 138,77 kB | Adobe PDF | Ver/Abrir |
