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https://hdl.handle.net/1822/62598| Título: | Label-free quantum dot conjugates for human protein IL-2 based on molecularly imprinted polymers |
| Autor(es): | Piloto, Margarida Ribeiro, David S. M. Rodrigues, S. Sofia M. Santos, João L. M. Sales, M. G. F. |
| Palavras-chave: | Quantum dots molecularly imprinted polymer conjugated-QDs protein interleukin-2 cancer biomarker |
| Data: | Fev-2020 |
| Editora: | Elsevier 1 |
| Revista: | Sensors and Actuators B: Chemical |
| Citação: | Piloto, Margarida; David S. M. Ribeiro; S. Sofia M. Rodrigues; João L. M. Santos; Sales, M. G. F., Label-free quantum dot conjugates for human protein IL-2 based on molecularly imprinted polymers. Sensors and Actuators B-Chemical, 304(127343), 2020 |
| Resumo(s): | Herein, the development of a fluorescent-based sensor by combining quantum dots (QDs) with molecularly-imprinted technology (MIP), intensively optimized to generate exceptional operating features is presented. This sensor is designed to target human interleukin-2 (IL-2) in synthetic human serum. IL-2 is a regulatory protein released as a triggered response from the immune system towards an inflammation. For this purpose, cadmium telluride (CdTe) QDs are prepared with 3-mercaptopropionic acid (MPA) and modified afterwards to produce an IL-2 imprinted polymer with methacrylic acid and N,N´-methylenebis(acrylamide), upon removal of the template under optimized conditions. During IL-2 rebinding, the fluorescence intensity of CdTe |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/62598 |
| DOI: | 10.1016/j.snb.2019.127343 |
| ISSN: | 0925-4005 |
| Versão da editora: | https://www.journals.elsevier.com/sensors-and-actuators-b-chemical |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
| Aparece nas coleções: |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| document_52177_1.pdf | 4,04 MB | Adobe PDF | Ver/Abrir |
