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https://hdl.handle.net/1822/65970
Título: | 4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase II and Antioxidant Enzymes in Mice |
Autor(es): | Zhao, Hongqiong Jiang, Zhihui Chang, Xuemei Xue, Huiting Yahefu, Wumaierjiang Zhang, Xiaoying |
Palavras-chave: | polyphenols 4-hydroxyphenylacetic acid 4-HPA acetaminophen APAP hepatotoxicity oxidative stress nuclear factor erythroid 2-related factor Nrf2 |
Data: | 2018 |
Editora: | Frontiers Media S.A. |
Revista: | Frontiers in Pharmacology |
Citação: | Zhao H, Jiang Z, Chang X, Xue H, Yahefu W and Zhang X (2018) 4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase II and Antioxidant Enzymes in Mice. Front. Pharmacol. 9:653. doi: 10.3389/fphar.2018.00653 |
Resumo(s): | Acetaminophen (APAP) overdose is the principal cause of drug-induced acute liver failure. 4-hydroxyphenylacetic acid (4-HPA), a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. This study seeks to investigate the ability of 4-HPA to protect against APAP-induced hepatotoxicity, as well as the putative mechanisms involved. Mice were treated with 4-HPA (6, 12, or 25 mg/kg) for 3 days, 1 h after the last administration of 4-HPA, a single dose of APAP was intraperitoneally infused for mice. APAP caused a remarkable increase of oxidative stress markers, peroxynitrite formation, and fewer activated phase II enzymes. 4-HPA increased Nrf2 translocation to the nucleus and enhanced the activity of phase II and antioxidant enzymes, and could thereby ameliorate APAP-induced liver injury. Studies reveal that 4-HPA, as an active area of bioactive dietary constituents, could protect the liver against APAP-induced injury, implying that 4-HPA could be a new promising strategy and natural hepatoprotective drug. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/65970 |
DOI: | 10.3389/fphar.2018.00653 |
ISSN: | 1663-9812 |
Versão da editora: | https://www.frontiersin.org/articles/10.3389/fphar.2018.00653/full |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | DBio - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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fphar-09-00653.pdf | 3,22 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons