Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/67152
Título: | The microbiome-metabolome crosstalk in the pathogenesis of respiratory fungal diseases |
Autor(es): | Gonçalves, Samuel Martins Lagrou, Katrien Oliveira, Cláudio Manuel Duarte Maertens, Johan A. Cunha, Cristina Amorim Carvalho, Agostinho |
Palavras-chave: | Animals Aspergillosis Aspergillus Dysbiosis Fungi Host-Pathogen Interactions Humans Inflammation Metabolome Mice Microbiota Mycoses Precision Medicine Respiratory Tract Infections Signal Transduction Symbiosis antifungal immunity fungal disease host genetics microbiome personalized medicine |
Data: | 2017 |
Editora: | Taylor and Francis |
Revista: | Virulence |
Citação: | Gonçalves, S. M., Lagrou, K., Duarte-Oliveira, C., et. al. (2017). The microbiome-metabolome crosstalk in the pathogenesis of respiratory fungal diseases. Virulence, 8(6), 673–684 |
Resumo(s): | Filamentous fungi of the genus Aspergillus are responsible for several superficial and invasive infections and allergic syndromes. The risk of infection and its clinical outcome vary significantly even among patients with similar predisposing clinical factors and pathogen exposure. There is increasing evidence that the individual microbiome supervises the outcome of the host-fungus interaction by influencing mechanisms of immune regulation, inflammation, metabolism, and other physiological processes. Microbiome-mediated mechanisms of resistance allow therefore the control of fungal colonization, preventing the onset of overt disease, particularly in patients with underlying immune dysfunction. Here, we review this emerging area of research and discuss the contribution of the microbiota (and its dysbiosis), including its immunoregulatory properties and relationship with the metabolic activity of commensals, to respiratory fungal diseases. Finally, we highlight possible strategies aimed at decoding the microbiome-metabolome dialog and at its exploitation toward personalized medical interventions in patients at high risk of infection. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/67152 |
DOI: | 10.1080/21505594.2016.1257458 |
ISSN: | 2150-5594 |
e-ISSN: | 2150-5608 |
Versão da editora: | https://www.tandfonline.com/doi/full/10.1080/21505594.2016.1257458 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Goncalves-2016-The-microbiome-metabolome-crosstalk.pdf Acesso restrito! | 1,29 MB | Adobe PDF | Ver/Abrir |