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https://hdl.handle.net/1822/76243
Título: | Permeability, anti-inflammatory and anti-VEGF profiles of steroidal-loaded cationic nanoemulsions in retinal pigment epithelial cells under oxidative stress |
Autor(es): | Fernandes, Ana R. Santos, Tiago dos Granja, Pedro L. Sanchez-Lopez, Elena Garcia, Maria L. Silva, Amelia M. Souto, Eliana B. |
Palavras-chave: | Cationic nanoemulsions Triamcinolone acetonide Vascular Endothelial Growth Factor Tumor Necrosis Factor alpha Choroidal neovascularization Tumor Necrosis Factor alpha, Choroidal neovascularization |
Data: | 5-Abr-2022 |
Editora: | Elsevier 1 |
Revista: | International Journal of Pharmaceutics |
Citação: | Fernandes, Ana R.; Santos, Tiago dos; Granja, Pedro L.; Sanchez-Lopez, Elena; Garcia, Maria L.; Silva, Amelia M.; Souto, Eliana B., Permeability, anti-inflammatory and anti-VEGF profiles of steroidal-loaded cationic nanoemulsions in retinal pigment epithelial cells under oxidative stress. International Journal of Pharmaceutics, 617(121615), 2022 |
Resumo(s): | Age-related macular degeneration (AMD) is defined as a degenerative, progressive and multifactorial disorder that affects the macula with a complex etiology. The retinal pigment epithelium is a monolayer of cells that has the function to separate the surface of the choroid from the neural retina that is involved in the signal transduction leading to vision. The blood-aqueous barrier and the blood retinal barrier limit the permeation of drugs into the retina and thereby reducing their efficacy. Triamcinolone acetonide (TA) is widely used as anti-inflammatory and immunomodulatory drug that promotes the inhibition of the inflammatory processes. The factors that stimulate or inhibit angiogenesis in AMD create a local balance that is responsible for the growth of sub-retinal neovascularization. In AMD, the main angiogenic stimulus is the vascular endothelial growth factor (VEGF). In this work, nanoemulsions with cationic surfactants (mono- and dicationic DABCO and quinuclidine) were produced to deliver TA, and were found to reduce the production of tumor necrosis factor alpha (TNF-), which stimulates the choroidal neovascularization development by upregulating the VEGF production, and consequently decreased the VEGF levels. Our results support the potential use of mono- and dicationic DABCO and quinuclidine-based cationic nanoemulsions for the delivery of TA in the treatment of AMD. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/76243 |
DOI: | 10.1016/j.ijpharm.2022.121615 |
ISSN: | 0378-5173 |
Versão da editora: | http://www.elsevier.com/locate/issn/03785173 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_55316_1.pdf Acesso restrito! | 891,01 kB | Adobe PDF | Ver/Abrir |