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https://hdl.handle.net/1822/81148
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Campo DC | Valor | Idioma |
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dc.contributor.author | Vieira, Sara F. | - |
dc.contributor.author | Gonçalves, Virgínia M. F. | - |
dc.contributor.author | Llaguno, Carmen P. | - |
dc.contributor.author | Macías, Felipe | - |
dc.contributor.author | Tiritan, Maria Elizabeth | - |
dc.contributor.author | Reis, R. L. | - |
dc.contributor.author | Ferreira, Helena Susana Costa Machado | - |
dc.contributor.author | Neves, N. M. | - |
dc.date.accessioned | 2022-12-15T09:25:17Z | - |
dc.date.available | 2022-12-15T09:25:17Z | - |
dc.date.issued | 2022-11-06 | - |
dc.identifier.citation | Vieira, S.F.; Gonçalves, V.M.F.; Llaguno, C.P.; Macías, F.; Tiritan, M.E.; Reis, R.L.; Ferreira, H.; Neves, N.M. On the Bioactivity of Echinacea purpurea Extracts to Modulate the Production of Inflammatory Mediators. Int. J. Mol. Sci. 2022, 23, 13616. https://doi.org/10.3390/ijms232113616 | - |
dc.identifier.issn | 1661-6596 | por |
dc.identifier.uri | https://hdl.handle.net/1822/81148 | - |
dc.description.abstract | Inflammatory diseases are the focus of several clinical studies, due to limitations and serious side effects of available therapies. Plant-based drugs (e.g., salicylic acid, morphine) have become landmarks in the pharmaceutical field. Therefore, we investigated the immunomodulatory effects of flowers, leaves, and roots from <i>Echinacea purpurea</i>. Ethanolic (EE) and dichloromethanolic extracts (DE) were obtained using the Accelerated Solvent Extractor and aqueous extracts (AE) were prepared under stirring. Their chemical fingerprint was evaluated by liquid chromatography–high resolution mass spectrometry (LC-HRMS). The pro- and anti-inflammatory effects, as well as the reduction in intracellular reactive oxygen and nitrogen species (ROS/RNS), of the different extracts were evaluated using non-stimulated and lipopolysaccharide-stimulated macrophages. Interestingly, AE were able to stimulate macrophages to produce pro-inflammatory cytokines (tumor necrosis factor -TNF-α, interleukin -IL-1β, and IL-6), and to generate ROS/RNS. Conversely, under an inflammatory scenario, all extracts reduced the amount of pro-inflammatory mediators. DE, alkylamides-enriched extracts, showed the strongest anti-inflammatory activity. Moreover, <i>E. purpurea</i> extracts demonstrated generally a more robust anti-inflammatory activity than clinically used anti-inflammatory drugs (dexamethasone, diclofenac, salicylic acid, and celecoxib). Therefore, <i>E. purpurea</i> extracts may be used to develop new effective therapeutic formulations for disorders in which the immune system is either overactive or impaired. | - |
dc.description.sponsorship | This research was funded by the Fundação para a Ciência e a Tecnologia (FCT) to the PhD grant of SFV (PD/BD/135246/2017 and COVID/BD/152012/2021) and the projects PATH (PD/00169/2013), FROnTHERA (NORTE-01-0145-FEDER-000023), Cells4_IDs (PTDC/BTM-SAL/28882/2017), and the NORTE 2020 Structured Project, co-funded by Norte2020 (NORTE-01-0145-FEDER-000021). This research was also partially supported by national funds by FCT through the projects UIDB/04423/2020 and UIDP/04423/2020 (Group of Natural Products and Medicinal Chemistry-CIIMAR) and ERDF, through the COMPETE—POFC program in the framework of the program PT2020. | - |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute | - |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/PD%2FBD%2F135246%2F2017/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/COVID%2FBD%2F152012%2F2021/PT | - |
dc.relation | PD/00169/2013 | - |
dc.relation | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBTM-SAL%2F28882%2F2017/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04423%2F2020/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04423%2F2020/PT | - |
dc.rights | openAccess | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | Echinacea purpurea extracts | por |
dc.subject | inflammation | por |
dc.subject | pro-inflammatory cytokines | por |
dc.subject | reactive oxygen and nitrogen species | por |
dc.subject | macrophages | por |
dc.subject | alkylamides | por |
dc.subject | phenols | por |
dc.subject | acids | por |
dc.subject | phenols/acids | por |
dc.title | On the bioactivity of Echinacea purpurea extracts to modulate the production of inflammatory mediators | - |
dc.type | article | - |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/23/21/13616 | - |
oaire.citationIssue | 21 | - |
oaire.citationVolume | 23 | - |
dc.date.updated | 2022-11-10T14:28:29Z | - |
dc.identifier.eissn | 1661-6596 | - |
dc.identifier.doi | 10.3390/ijms232113616 | - |
dc.identifier.pmid | 36362404 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | International Journal of Molecular Sciences | - |
oaire.version | VoR | - |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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ijms-23-13616-v3.pdf | 3,99 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons