Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/81148
Título: | On the bioactivity of Echinacea purpurea extracts to modulate the production of inflammatory mediators |
Autor(es): | Vieira, Sara F. Gonçalves, Virgínia M. F. Llaguno, Carmen P. Macías, Felipe Tiritan, Maria Elizabeth Reis, R. L. Ferreira, Helena Susana Costa Machado Neves, N. M. |
Palavras-chave: | Echinacea purpurea extracts inflammation pro-inflammatory cytokines reactive oxygen and nitrogen species macrophages alkylamides phenols acids phenols/acids |
Data: | 6-Nov-2022 |
Editora: | Multidisciplinary Digital Publishing Institute |
Revista: | International Journal of Molecular Sciences |
Citação: | Vieira, S.F.; Gonçalves, V.M.F.; Llaguno, C.P.; Macías, F.; Tiritan, M.E.; Reis, R.L.; Ferreira, H.; Neves, N.M. On the Bioactivity of Echinacea purpurea Extracts to Modulate the Production of Inflammatory Mediators. Int. J. Mol. Sci. 2022, 23, 13616. https://doi.org/10.3390/ijms232113616 |
Resumo(s): | Inflammatory diseases are the focus of several clinical studies, due to limitations and serious side effects of available therapies. Plant-based drugs (e.g., salicylic acid, morphine) have become landmarks in the pharmaceutical field. Therefore, we investigated the immunomodulatory effects of flowers, leaves, and roots from <i>Echinacea purpurea</i>. Ethanolic (EE) and dichloromethanolic extracts (DE) were obtained using the Accelerated Solvent Extractor and aqueous extracts (AE) were prepared under stirring. Their chemical fingerprint was evaluated by liquid chromatography–high resolution mass spectrometry (LC-HRMS). The pro- and anti-inflammatory effects, as well as the reduction in intracellular reactive oxygen and nitrogen species (ROS/RNS), of the different extracts were evaluated using non-stimulated and lipopolysaccharide-stimulated macrophages. Interestingly, AE were able to stimulate macrophages to produce pro-inflammatory cytokines (tumor necrosis factor -TNF-α, interleukin -IL-1β, and IL-6), and to generate ROS/RNS. Conversely, under an inflammatory scenario, all extracts reduced the amount of pro-inflammatory mediators. DE, alkylamides-enriched extracts, showed the strongest anti-inflammatory activity. Moreover, <i>E. purpurea</i> extracts demonstrated generally a more robust anti-inflammatory activity than clinically used anti-inflammatory drugs (dexamethasone, diclofenac, salicylic acid, and celecoxib). Therefore, <i>E. purpurea</i> extracts may be used to develop new effective therapeutic formulations for disorders in which the immune system is either overactive or impaired. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/81148 |
DOI: | 10.3390/ijms232113616 |
ISSN: | 1661-6596 |
e-ISSN: | 1661-6596 |
Versão da editora: | https://www.mdpi.com/1422-0067/23/21/13616 |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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ijms-23-13616-v3.pdf | 3,99 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons