Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/88560
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Pierantoni, Lara | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Silva-Correia, Joana | por |
dc.contributor.author | Oliveira, Joaquim M. | por |
dc.contributor.author | Heavey, Susan | por |
dc.date.accessioned | 2024-02-06T11:45:14Z | - |
dc.date.issued | 2023-11 | - |
dc.identifier.citation | Pierantoni L., Reis R. L., Silva-Correia J., Oliveira J. M., Heavey S. Spatial -omics technologies: the new enterprise in 3D breast cancer models, Trends in Biotechnology, Vol. 41, Issue 12, pp. 1488-1500, doi:10.1016/j.tibtech.2023.07.003, 2023 | por |
dc.identifier.issn | 0167-7799 | por |
dc.identifier.uri | https://hdl.handle.net/1822/88560 | - |
dc.description.abstract | The fields of tissue bioengineering, -omics, and spatial biology are advancing rapidly, each offering the opportunity for a paradigm shift in breast cancer research. However, to date, collaboration between these fields has not reached its full potential. In this review, we describe the most recently generated 3D breast cancer models regarding the biomaterials and technological platforms employed. Additionally, their biological evaluation is reported, highlighting their advantages and limitations. Specifically, we focus on the most up-to-date -omics and spatial biology techniques, which can generate a deeper understanding of the biological relevance of bioengineered 3D breast cancer in vitro models, thus paving the way towards truly clinically relevant microphysiological systems, improved drug development success rates, and personalised medicine approaches. | por |
dc.description.sponsorship | L.P. thanks the Portuguese Foundation for Science and Technology (FCT) for the attributed PhD scholarship (reference PD/BD/ 150520/2019). This research is developed under the project BAMOS (H2020-MSCARISE-2016-734156), funded by the European Union under the Horizon 2020 Programme. This work was partially supported by IET A. F. Harvey Engineering Research Award 2018 (ENG The Cancers 2022). The authors thank the financial support provided under the project HEALTH-UNORTE (reference NORTE-01-0145-FEDER-000039) funded by the Norte Portugal Regional Coordination and Development Commission (CCDR-N) under the NORTE2020 Program. J.S-C. acknowledges the individual contract under the project LA ICVS-3Bs, references UIDB/50026/2020 and UIDP/50026/2020, financed by national funds through the FCT and, when eligible, cofinanced by EU funds. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/PD%2FBD%2F150520%2F2019/PT | por |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/734156/EU | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50026%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50026%2F2020/PT | por |
dc.rights | restrictedAccess | por |
dc.subject | -omics technologies | por |
dc.subject | Bioengineered 3D cancer models | por |
dc.subject | Breast cancer | por |
dc.subject | Spatial biology | por |
dc.subject | Translation | por |
dc.title | Spatial -omics technologies: the new enterprise in 3D breast cancer models | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0167779923002123 | por |
dc.comments | http://3bs.uminho.pt/node/21049 | por |
oaire.citationStartPage | 1488 | por |
oaire.citationEndPage | 1500 | por |
oaire.citationIssue | 12 | por |
oaire.citationVolume | 41 | por |
dc.date.updated | 2024-02-06T09:19:20Z | - |
dc.identifier.eissn | 1879-3096 | por |
dc.identifier.doi | 10.1016/j.tibtech.2023.07.003 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 37544843 | por |
sdum.journal | Trends in Biotechnology | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
21049-1-s20-s0167779923002123-main.pdf Acesso restrito! | 2,29 MB | Adobe PDF | Ver/Abrir |