Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/88560
Título: | Spatial -omics technologies: the new enterprise in 3D breast cancer models |
Autor(es): | Pierantoni, Lara Reis, R. L. Silva-Correia, Joana Oliveira, Joaquim M. Heavey, Susan |
Palavras-chave: | -omics technologies Bioengineered 3D cancer models Breast cancer Spatial biology Translation |
Data: | Nov-2023 |
Editora: | Elsevier 1 |
Revista: | Trends in Biotechnology |
Citação: | Pierantoni L., Reis R. L., Silva-Correia J., Oliveira J. M., Heavey S. Spatial -omics technologies: the new enterprise in 3D breast cancer models, Trends in Biotechnology, Vol. 41, Issue 12, pp. 1488-1500, doi:10.1016/j.tibtech.2023.07.003, 2023 |
Resumo(s): | The fields of tissue bioengineering, -omics, and spatial biology are advancing rapidly, each offering the opportunity for a paradigm shift in breast cancer research. However, to date, collaboration between these fields has not reached its full potential. In this review, we describe the most recently generated 3D breast cancer models regarding the biomaterials and technological platforms employed. Additionally, their biological evaluation is reported, highlighting their advantages and limitations. Specifically, we focus on the most up-to-date -omics and spatial biology techniques, which can generate a deeper understanding of the biological relevance of bioengineered 3D breast cancer in vitro models, thus paving the way towards truly clinically relevant microphysiological systems, improved drug development success rates, and personalised medicine approaches. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/88560 |
DOI: | 10.1016/j.tibtech.2023.07.003 |
ISSN: | 0167-7799 |
e-ISSN: | 1879-3096 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S0167779923002123 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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21049-1-s20-s0167779923002123-main.pdf Acesso restrito! | 2,29 MB | Adobe PDF | Ver/Abrir |