Development and characterization of nanostructured lipid carriers for cannabidiol delivery

doi:10.1016/j.foodchem.2023.138295

Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/89366

Título:	Development and characterization of nanostructured lipid carriers for cannabidiol delivery
Autor(es):	Vardanega, Renata Lüdtke, Fernanda Luisa Loureiro, Luís Carlos Sá Gonçalves, Raquel Filipa Silva Pinheiro, A. C. Vicente, A. A.
Palavras-chave:	Drug Carriers Health Promotion Soybean Oil Emulsifying Agents Particle Size Polysorbates Nanoparticles Cannabidiol Nanostructures Cannabinoids Emulsifiers Lipid nanoparticles Lipid-based systems Nanoparticles characterization Physical stability
Data:	30-Mai-2024
Editora:	Elsevier Science BV
Revista:	Food Chemistry
Citação:	Vardanega, R., Lüdtke, F. L., Loureiro, L., Gonçalves, R. F. S., Pinheiro, A. C., & Vicente, A. A. (2024, May). Development and characterization of nanostructured lipid carriers for cannabidiol delivery. Food Chemistry. Elsevier BV. http://doi.org/10.1016/j.foodchem.2023.138295
Resumo(s):	This study evaluated the physicochemical characteristics of nanostructured lipid carriers (NLCs) as a potential vehicle for cannabidiol (CBD), a lipophilic molecule with great potential to promote health benefits. NLCs were produced using hemp seed oil and fully-hydrogenated soybean oil at different proportions. The emulsifiers evaluated were soybean lecithin (SL), Tween 80 (T80) and a mixture of SL:T80 (50:50). CBD was tested in the form of CBD-rich extract or isolate CBD, to verify if it affects the NLCs characteristics. Based on particle size and polydispersity, SL was considered the most suitable emulsifier to produce the NLCs. All lipid proportions evaluated had no remarkable effect on the physicochemical characteristics of NLCs, resulting in CBD-loaded NLCs with particle size below 250 nm, high CBD entrapment efficiency and CBD retention rate of 100% for 30 days, demonstrating that NLCs are a suitable vehicle for both CBD-rich extract or isolate CBD.
Tipo:	Artigo
Descrição:	Supplementary data to this article can be found online at https://doi.org/10.1016/j.foodchem.2023.138295.
URI:	https://hdl.handle.net/1822/89366
DOI:	10.1016/j.foodchem.2023.138295
ISSN:	0308-8146
Versão da editora:	https://www.sciencedirect.com/science/article/pii/S0308814623029138
Arbitragem científica:	yes
Acesso:	Acesso aberto
Aparece nas coleções:	CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series